What is SDT?
CureGBM is dedicated to pioneering a breakthrough in brain tumour treatment through innovative sonodynamic therapy. Our non-invasive approach gently targets tumours, improving patient outcomes and enhancing their quality of life. Join us in our mission to transform healthcare.
What is Sonodynamic Therapy (SDT)?
Sonodynamic Therapy (SDT) is an innovative, non-invasive treatment designed to target and destroy cancer cells using sound waves.
Patients drink a drug called 5-ALA which has been used by neurosurgeons for many years. This drug accumulates inside tumour cells and allows us to know where the tumour is in the brain.
We then use Ultrasound energy and focus it onto the tumour inside the brain, and this energy together with the 5-ALA creates a special reaction inside the tumour cell, causing it to die, whilst sparing surrounding normal brain tissue.
The sonosensitiser being used in our clinical trial is ALA, which has been safely used by neurosurgeons for 20yrs.
Unlike radiation or chemotherapy, SDT is highly targeted and gentle. It reaches deep into the brain, making it ideal for treating tumours that are hard to access. The treatment is silent, painless, and doesn’t require surgery.
SDT is still being refined through research, but early clinical trial results are incredibly promising for people with glioblastoma. It offers a new way to fight cancer with precision, minimal side effects, and maximum impact.
SDT targets ALL cancerous cells, regardless of molecular subtype and will localise to pockets of tumour invisible to the surgeon’s microscope during surgery and not seen on MRI performed post-treatment.
Early SDT studies have shown more than double the survival benefit of other experimental therapies. Experimental therapies have shown no more than 3-4 months survival benefit, using treatments such as immunotherapy (tumour vaccines), tumour-treating fields, nanoparticle delivery or ultrasound to open the Blood Brain Barrier for novel chemotherapeutics.
This is why we are bringing this treatment to Europe from America, early trial results can be seen here: https://www.youtube.com/watch?v=TD4KaKuCeOk